Endocrine Abstracts

Primary hyperparathyroidism (PHP) is a common endocrine disorder. It is due to a single parathyroid adenoma in 80% of cases, most of the remainder due to hyperplasia of all four parathyroid glands. The only curative procedure is parathyroidectomy, but preoperative localization can be difficult. Isotope scanning with sestaMIBI is considered to be useful in localizing any parathyroid adenoma to help guided surgery. The aim of this study is demonstrated the influence of biochemic...

In postmenopausal women with clinical hyperandrogenism Cushing’s syndrome and adrenal/ovarian neoplasms must be excluded, but radiological and biochemical studies are not always useful for localizing the source of androgens.Case 1: A 75-year-old woman developed alopecia and progressive hair growth on the chest and abdomen over 4 months. Five years before a successful parathyroidectomy had been carried out. Hormonal evaluation: Testosterone (T): 5.84...

In our centre we use CNB for routine study of thyroid nodules since 2005. Four diagnostic categories for CNB’s results have been standardised: insufficient; benign; follicular proliferation (FOL), including follicular and oncocytic neoplasms; and malignant. Diagnosis of FOL was defined according to the presence of microfollicular patterned biopsies with scant or absent colloid, sometimes with minimal pleomorphism or discrete nuclear changes. This category could be equival...

TSH level has been proposed as a thyroid malignancy predictor in nodular thyroid disease. In addition, several clinical studies have reported that higher preoperative serum TSH levels were associated with more advanced stages of differentiated thyroid cancer (DTC) at the time of diagnosis.Methods: We collected retrospectively preoperative serum TSH from patients diagnosed of papillary thyroid cancer (PTC) who had undergone total thyroidectomy during the ...

Thyroid carcinoma is a rare extraintestinal manifestation of colonic familial adenomatous polyposis (FAP). This syndrome is caused by germline mutations in adenomatous polyposis coli (APC) gene, on chromosome 5q21-q22. Many patients manifest various extracolonic features: upper gastrointestinal adenomas, congenital hypertrophic retinal pigment epithelial lesions, desmoids tumors, and thyroid, adrenal and brain cancers. It has been reported an incidence of 1.2% of thyroid carci...

Incidental thyroid carcinoma includes thyroid carcinomas detected after surgery in patients whose thyroid has been correctly studied with no data of malignancy. Lately, the widely spread use of image techniques and thorough search of thyroid nodule complains, have lead to a growing number of thyroid carcinomas. But still there are some of these incidentally discovered after thyroidectomy.We report 98 cases of thyroid carcinomas incidentally found from a ...

Current treatment for acromegaly includes dopamine agonists (DA), somatostatin receptor ligands (SRL) and GH receptor antagonists (GHRA). DA in monotherapy, is less than 10% effective achieving control of the disease, and its efficacy in addition to ongoing SRL is less studied, without obvious determining factors of response. We report 2 operated patients with incomplete response to SRL and to whom Cabergoline addition led to disease control.Case 1: A ma...

Autoimmune polyendocrinopathy syndromes (APS) gather a wide range of diseases. The association of autoimmune thyroid disease (ATD) with other organ specific diseases is frequent. Atrophic body gastritis (ABP) is characterized by the loss of ClH and intrinsic factor (IF) production. Both ATD and ABP are known to be associated since 1960 but there are scarce publications describing its clinical features.We review patients with this association selected fro...

Surgery followed by 131I ablative therapy (IAT) is the usual treatment for patients with differentiated thyroid carcinoma (DTC). Thyroglobulin levels obtained 9–12 months after IAT under TSH stimulation (Tg2) is a very reliable marker for the presence of thyroid tissue. The value of stimulated thyroglobulin previous to ablation (Tg1) is more controversial. The aim of this study was to examine the relationship between Tg1 and Tg2.Material ...

Introduction: Abnormal thyroid function is the most common disease in endocrinology and its screening of made by plasmatic (TSH), followed by (fT4) determination if abnormal. (fT3) determination is only used when pathological (TSH) and normal (fT4) are found, even if there is no evidence supporting this procedure, apart from the greater technical difficulty of measuring (fT3) due to its lower plasma concentration.Material and Methods: Observational retro...